FERTILITY EFFECT OF CYCAS CIRCINALIS AND IONIDIUM SUFFRUTICOSUM IN SENILITY INDUCED STERILITY OF MALE WISTAR RATS – A HISTOMORPHOMETRIC STUDY

Ageing is associated with the diminished function of various tissues in the body. The gonadal function declines with age. In male, there is progressive atrophy of the sperm producing elements of the testes, resulting in diminished spermatogenesis. Many natural nontoxic herbs were found to enhance the fertility in male. The study is done to evaluate the effect of Cycas circinalis (Cc) and Ionidium suffruticosum (Is) in improving the fertility of senility induced sterility of male albino rats. A total of 24 healthy young male albino rats were selected and six animals were randomly distributed into 4 groups. The groups include normal control, positive control, experimental I and Experimental II. Normal control was administered sterile water orally; positive control was administered testosterone hormone subcutaneously (10 µg/kg body weight), experimental I group was administered ethanolic extract of Cycas circinalis (200 mg/kg body weight) and Experimental II group was administered ethanolic extract of Ionidium suffruticosum (200 mg/kg body weight) orally for 30 days. Various parameters such as sexual behaviour, weight of animals, dimension and weight of testes, hormone, semen and histological analysis were compared among the groups. Restitution of fertility was compared with the normal fertile controls rats. The drug’s efficacy was compared by one way ANOVA among the groups and both the herbs showed significant improvement in all the parameters in experimental rats when compared to control rats. The herbs were found to be effective on the gonads of senility induced sterility of male Albino rats.