FERULIC ACID – A COMPREHENSIVE PHARMACOLOGY OF AN IMPORTANT BIOFLAVONOIDAbstract
Ferulic acid (4-hydroxy-3-methoxycinnamic acid) is an phenolic compound and an antioxidant found in many staple foods, such as fruits, vegetables, cereals, coffee and in plant constituent exhibiting a wide range of therapeutic effects such as anticancer, antidiabetic, cardio protective and neuroprotective, anti-inflammatory activity. The present review summarizes the most recent literature on FA including its pharmacological actions, preclinical and clinical studies, reported mechanisms of actions, pharmacokinetic profile, precautions and safety parameters and its interaction with other drugs and plasma protein. The article also deals with the latest research updates as well as avenues for further research to elucidate the positive effects of this widespread phenolic compound for a better understanding of its potential applications in health and disease. It may subsequently help in the development and design of suitable pharmaco-active compounds.
Kashmira J. Gohil, Shashank B. Kshirsagar* and Rajkumari S. Sahane
Department of Pharmacology, Sinhgad College of Pharmacy, Vadgaon (Bk), Pune-41, Maharashtra, India
12 November, 2011
02 December, 2011
17 February, 2012