FLASH RELEASE ORAL FILM OF CANDESARTAN CILEXETIL FORMULATION AND IN-VITRO EVALUATIONAbstract
In the present study, to develop a novel flash release fast dissolving oral film of candesartan cilexetil to achieve rapid dissolution and further improve the bioavailability of the drug. Also, to resolve the swallowing problems in pediatrics, geriatric patients by rapid dissolution in saliva and improve the patient compliance. Fast dissolving flash release oral flim of candesartan cilexetil was formulated using HPMCE5, HPMCE15 and HPMCK15 as film-forming polymers. Glycerol, polyethylene glycol and propylene glycol were used as a plasticizer by solvent casting method and found to satisfy the mouth dissolving film and other film parameters. The formulated films of candesartan cilexetil were evaluated for parameters like thickness, weight variation, folding endurance, SEM, surface pH disintegration time, drug content, in-vitro dissolution studies and kinetics studies. The in-vitro disintegration time of the optimized batch F5 was found to be 56 ± 0.12 sec. The films exhibited satisfactory thickness and folding endurance. The optimized batch F5 (HPMCE15) showed a faster disintegrating time, showing 96.02 ± 0.49 drug release within 30 min. The in-vitro release profile of optimized formulation F5 followed a first-order kinetic model with non-fickian diffusion law.
Chandrasekar G, Abdual Hasan Sathali A *, Umamaheswari D and Prabhu R
Department of Pharmaceutics, College of Pharmacy (COP), Madurai Medical College, Madurai, Tamil Nadu, India.
28 August 2020
05 July 2021
06 July 2021
01 September 2021