FLAVONOIDS: THERAPEUTIC POTENTIAL OF NATURAL PHARMACOLOGICAL AGENTSAbstract
Flavonoids are the natural compound widely distributed in plant kingdom, it is responsible for the various colors exhibited by bark, leaves, flowers, fruits and seeds of plants. They are the secondary metabolites of plant with significant antioxidant properties. Flavonoids have antioxidant, sedative, antidepressant, anticonvulsant, anti-proliferative, anti-inflammatory, anti-microbial, anticancer, cardioprotective, antihypertensive, antiulcerogenic, antidiabetic and hepatoprotective activity. Many researchers have revealed that the above mentioned pharmacological actions are mainly due to its antioxidant property. Flavonoids have effect on mammalian enzymes like protein kinases, alpha-glucosidase and aldose reductase, thereby regulate multiple cellular signaling pathway that were altered during disease conditions. Various researches on flavonoids are in progress due to its versatile health benefits. En number of flavonoids are available in the market as pharmaceutical products because of its cost effective bulk production and health benefits. The present review is focused on the classification, metabolism, pharmacological and biological actions and flavonoid supplement available in market.
K.S. Sridevi Sangeetha, S. Umamaheswari *, C. Uma Maheswara Reddy and S. Narayana Kalkura
Department of Pharmacology, Faculty of Pharmacy, Sri Ramachandra University, porur, Chennai, Tamilnadu, India.
04 May, 2016
15 June, 2016
29 June, 2016
01 October 2016