FLOATING MICROSPHERES: A NOVEL EMERGING TREND IN GASTRO RETENTIVE DRUG DELIVERYAbstract
Oral Conventional dosage forms offer no control over the release of drug from the dosage form, which leads to variations in plasma drug levels; gastric emptying and gastric resident time are two another important factors that have a significant effect on the therapeutic efficacy of drug and it causes changes in the retention time of the drug. Accordingly, Floating microspheres is one of the most dependable and inventive techniques among all the gastro retentive drug delivery systems to overcome from these problems. Floating microspheres are mainly obtaining importance because of their vast suitability in the targeting of drugs to the stomach, undergo action and scattered uniformly over the gastric fluid to avoid the changes of gastric emptying and enlarge the liberation of the drug. This system also allows vastly in the fabrication of new controlled and delayed-release oral formulations, thus Expanding revolutions in pharmaceutical Expansion. The present review, in brief, says the physiology of the Intestinal gastric tract and elements governs the gastro retentive drug delivery system. This review aims to illuminate the recent literature like the importance of floating microspheres in the Novel drug delivery system, methods of preparation, differentiation of Floating microspheres, and recent scientific advances in formulating floating microspheres using different classes of drugs.
A. R. Pavan *, X. F. Grace and S. R. Ramakrishnan
Department of Pharmaceutics, Sri Ramachandra institute of Higher Education and Research, Porur, Chennai, Tamil Nadu, India.
27 April 2020
02 May 2021
11 May 2021
01 June 2021