FORMULA OPTIMIZATION OF IMMEDIATE RELEASE TABLET OF CLOPIDOGREL BISULPHATE FREE FROM SURFACE IRREGULARITIESAbstract
Clopidogrel Bisulphate is an oral, thienopyridine class antiplatelet agent used to inhibit blood clots in coronary artery disease, peripheral vascular disease, and cerebrovascular disease. Immediate release tablet of clopidogrel bisulphate (form II) was prepared by using direct compression technique. Clopidogrel Bisulphate is very hygroscopic and show rapid degradation when processed with alkali salt as Mg++, Ca++ etc picking, sticking, or other kind of surface irregularities are other processing problems associated with it so, selection of excipients were done for preparation of stable dosage form which was free from any surface irregularities. Lubricants used were hydrogenated castor oil and poly-12-hydroxy stearate.
Hardik Jain, Vimal Arora , Jitendra Gupta and Anil Bhandari
M.Pharm (Research Scholar), Vpo-Nayagaon, Teh- Kherwara, Dist.- Udaipur, Rajasthan 313804, India
26 May, 2011
24 November, 2011
28 November, 2011
01 December, 2011