FORMULATION AND CHARACTERIZATION OF SILVER NANOPARTICLE COATED WITH NATURAL pH STIMULI POLYMERAbstract
Carboplatin is the first-line choice of drug for ovarian cancer. In this investigation, we have prepared carboplatin silver nanoparticles (CSNP’s) by electrostatic adsorption. The size range was found to be 53-87 nm and the zeta potential was in the range of -36 to -61. After coating with hyaluronic acid and drug the size was observed to be around 80 nm and zeta potential was -41. After coating the monodisperse particles with a narrow polydispersity index value of 0.49-0.51 were obtained. The pH of silver nanoparticles without coating was in between 5.1-5.9. Atomic force microscopy confirms the spherical shape of nanoparticles. The entrapment was found to be 70-87%. Formulation F3 was found to have more entrapment efficiency and the release extended up to 6 h in phosphate buffer saline pH 7.4. The uniform concentration of trisodium citrate and tannic acid as a reducing agent along with high concentration of hyaluronic acid in F3 formulation able to entrap high drug load and release for an extended period. The drug release follows zero-order kinetics. This might provide a promising alternative for the development of an anticancer drug delivery system.
R. Priyadharshini and V. Sankar *
Department of Pharmaceutics, PSG College of Pharmacy, Peelamedu, Coimbatore, Tamil Nadu, India.
11 May 2019
18 February 2020
24 February 2020
01 March 2020