FORMULATION AND CHARACTERIZATION OF SOLID DISPERSIONS OF A POORLY SOLUBLE FENOFIBRATE
Abstract| Solid dispersion is one of these methods, which was most widely and successfully applied to improve the solubility, dissolution rates and consequently the bioavailability of poorly soluble drugs. The solid dispersions based on the concept that the drug is dispersed in an inert water-soluble carrier at solid state. Several water soluble carriers such as methyl cellulose, urea, lactose, citric acid, polyvinyl pyrrolidone and polyethylene glycols 4000 and 6000 are used as carriers for solid dispersion. Thus the solid dispersion technique can be successfully used for the improvement of dissolution of Fenofibrate. Various solvents, carrier materials, diluents, disintegrating agents, lubricants has been used for the preparation of solid dispersion of fenofibrate. Over the years, a variety of solubilization techniques have been studied and widely used, by many estimates up to 40 per cent of new chemical entities discovered by the pharmaceutical industry today are poorly soluble or lipophilic compounds. The solubility issues complicating the delivery of these new drugs also affect the delivery of many existing drugs. The various techniques are available for enhancement of solubility. Solid dispersion is one of the most promising approach for solubility enhancement. Different methods are also been used for preparation of solid dispersions such as Melting method, Solvent method, Melting solvent method (melt evaporation), Melt extrusion method, Lyophilisation Technique, Melt Agglomeration Process, The Use Of Surfactant, Electrospinning and Super Critical Fluid (SCF) Technology. Preformulation and evaluation parameters in this study explain about the flowability and acceptability of the prepared formulations. DSC studies explain about the compatibility between the different excipients used in the formulations. |
Article Information
50
3004-3017
892 KB
4255
English
IJPSR
A. Prashanth Kumar
Prasad institute of Pharmaceutical Sciences, Jalgaon, Telangana, India
prashanthalay14@Gmail.com
24 January, 2014
03 March, 2014
03 May, 2014
http://dx.doi.org/10.13040/IJPSR.0975-8232.5(7).3004-17
01 July, 2014
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