FORMULATION AND DEVELOPMENT OF CURCUMIN AND MAG LOADED ENTERIC COATED TABLET IN THE TREATMENT OF IBDAbstract
The incidence of Inflammatory Bowel Disease (IBD) is now rising in developing countries and increasingly considered an emerging global disease. IBD is a chronic, intermittent disease. Symptoms of IBD varies from person to person and segment of the intestinal tract involved. IBD diagnosis depends on the various test, which requires blood testing, stool testing, endoscopy, biopsies as well as physical examination with patient history study. The most common side effects of antibiotics in the treatment of IBD are killing microflora with bacteria; hence it makes the condition worst rather than curing. Curcumin has many pharmacological such as anti-inflammatory, anti-oxidative stress, and anti-catabolic activity, which play an important role in mitigating in CD and UC in IBD. Monoammonium glycyrrhizinate (MAG) was recognized as a compound possessing antimicrobial properties, MAG tested many researchers using the agar diffusion method, which shows significant antibacterial activities against gram-positive (Bacillus subtilis, Staphylococcus aureus) as well as gram-negative bacteria (Escherichia coli, Pseudomonas aeruginosa), MAG also decrease the permeability of intestine in IBD which inhibit autoimmune attack. This present study focuses on treating the IBD without disturbing the microflora in an effective way. Thus, the formulating enteric coating drug delivery system containing Curcumin and MAG in combination with local action for healing IBD is possible. This facilitates drug release at the disease location, which gives maximum therapeutic effect and treat IBD with more efficiently.
S. R. Divekar * and V. R. Vaidya
Department of Pharmaceutics, Dr. D. Y. Patil College of Pharmacy, Pune, Maharashtra, India.
22 February 2020
13 May 2020
10 September 2020
01 February 2021