FORMULATION AND EVALUATION OF α-TOCOPHEROL ACETATE TABLET BY LIQUID-SOLID TECHNOLOGY

The objective of this research was to develop a liquisolid (LS) formulation of dl-α tocopherol acetate with improved dissolution properties and evaluate its strength to excipient modifications as well as its stability. Microcrystalline cellulose (MCC) and sodium starch glycolate (SSG) was employed as carrier material and disintegrant respectively for preparing LS compacts. Colloidal silicon dioxide (CSD) was selected as coating materials. All the precompression parameters such as tapped density, bulk density, carr’s index, hausner’s ratio and angle of repose show the good flow properties of the formulation. UV and FTIR evaluated the physicochemical properties of the liquisolid system. All studies revealed that no interaction between drug and the carrier. The drug release rates of liquisolid compacts were specifically higher as compared to regular tablets. The specific surface areas of coating materials affected the flow properties of the blends, and the particle sizes of coating materials affected the dissolution rate. The selected formulation demonstrated stability for atleast 3 months. The F3 formulation is found to be the optimized formulation. The liquisolid system was an effective approach to prepare dl-ɑ tocopherol acetate tablets with enhanced dissolution properties.