FORMULATION AND EVALUATION OF AL+3 -INDUCED GELLAN GUM-DILLENIA INDICA L. FRUIT GUM-BLENDED MICROBEADS FOR SUSTAINED DRUG RELEASEAbstract
The current communication deals with the development of Al3+ -ion induced ionotropically gelled microbeads made of deacetylated gellan gum (GG) and Dillenia indica L. fruit gum (DG) blends for sustained release of drugs. Aceclofenac (ACE) was utilized as a model drug candidate in the current study. These GG-DG microbeads of ACE were formulated by ionotropic gelation using AlCl3 as ionotropic cross-linker. In this microbead formulation, various formulation parameters like amount of GG, amount of DG and concentration of AlCl3 were varied and analyzed. These various GG-DG microbeads of ACE demonstrated ACE entrapment efficiency of 24.94 ± 0.32 to 72.76 ± 2.83% and an average micro-bead size of 698.56 ± 19.76 to 955.08 ± 40.62 µm. ACE releasing from various GG-DG microbeads in the in-vitro study was found to be sustained over 8 h. Optimized GG-DG microbeads of ACE followed the Korsmeyer-Peppas model (R2 = 0.9918 to 0.9982) with super case-II transport mechanism of a drug (ACE) releasing. The optimized GG-DG microbeads of ACE (F-O) were also characterized by various instrumental analyses like SEM, FTIR, and DSC analyses.
S. Maity * and S. K. Mahapatra
Department of Pharmaceutics, Seemanta Institute of Pharmaceutical Sciences, Jharpokharia, Mayurbhanj, Odisha, India.
26 February 2020
04 July 2020
11 July 2020
01 February 2021