FORMULATION AND EVALUATION OF BIOADHESIVE BUCCAL TABLETS OF ENALAPRIL MALEATEAbstract
Enalapril maleate competitively inhibits the ACE to hinder the production of angiotensin II, a key component of the rennin angiotensin aldosterone system that promotes vasoconstriction and reabsorption of sodium ion in the kidney, overall decrease in blood pressure. The study’s main objective was to formulate and evaluate bioadhesive buccal tablets to avoid the first-pass metabolism in the liver and patient acceptance. Bioadhesive buccal tablets were prepared by direct compression method using bioadhesive polymers like Chitosan, Carbopol 934, and HPMC K100M in different ratios to a drug. The physicochemical compatibility of drugs and polymers was studied by FT-IR spectroscopy. Prepared tablets were evaluated for permeation study through the porcine buccal mucosa, in-vitro drug release, swelling index, moisture absorbance, surface pH; among the prepared formulation containing F6 Shows maximum drug release 88.5 % in 8 h the optimized formulation F6 showed surface pH 6.9 and swelling index 82.2%. The formulation followed Peppas order release kinetic non Fickian kinetics.
V. R. Joan, S. N. Santha and K. Balamurugan *
Department of Pharmay, FEAT, Annamalai University, Annamalai Nagar, Chidambaram, Tamil Nadu, India.
31 March 2020
20 July 2020
20 October 2020
01 April 2021