FORMULATION AND EVALUATION OF BUTENAFINE HYDROCHLORIDE LOADED CUBOSOMAL GELAbstract
The aim of this research was to develop and evaluate a cubosomal gel for the treatment of skin diseases such as athlete’s foot (tineapedis), ringworm (tineacruris) and ringworm (tineacorporis). To increase the penetration of the drug and to provide longer duration of treatment this study was performed. Cubosomes are a novel nanoparticle system loaded with butenafine hydrochloride as an antifungal agent. Cubosomes were designed and approached using a top-down approach. Top-down approach was easy and repeatable also. Cubosomes loaded with Butenafine hydrochloride were prepared by a simple emulsification method using different concentrations of lipid phase GMO and poloxamer 407 enclosed in a cubic gel matrix. The prepared cubosomal dispersion was characterized by Drug Entrapment efficiency and particle size. Optimal formulation of cubosomes were incorporated into carbopol-based hydrogels to form cubosomes hydrogels (cubosomal-gels) characterized by physical morphology, drug release studies, pH, viscosity, and spreadability studies. Among all formulations (F7), was found to have the highest drug release at 24 h of 78.693±0.117%, entrapment efficiency (86.517±0.146) and particle size of 189.71nm.
Ritik Chauhan and Nirmala
School of Pharmaceutical Sciences, Rayat and Bahra University, V.P.O. Sahauran, Tehsil Kharar, Mohali, Punjab, India.
30 March 2023
22 May 2023
31 May 2023
01 November 2023