FORMULATION AND EVALUATION OF CHITOSAN BASED BUCCAL PATCH OF GRANISETRON HYDROCHLORIDE
AbstractGranisetron hydrochloride is most commonly used as an antiemetic agent in treatment associated with cancer chemotherapy induced nausea and vomiting. If the dosage form is designed in sustain release it provide more advantage for the antiemetic therapy. The purpose of this research was to study mucoadhesive buccal patches of Granisetron hydrochloride using the bioadhesive polymers chitosan and sodium alginate. Patches containing chitosan in 1.5%w/v and sodium alginate 2%w/v had maximum percentage of in vitro drug release and ex vivo drug permeation upto 8 hr. The swelling index was proportional to chitosan and sodium alginate content. The surface pH of all patches was found to be satisfactory (7.0 ± 1.5), close to neutral pH; hence, buccal cavity irritation will not be a problem with these patches. The mechanism of drug release was found to be Higuchi (matrix). The formulation F6 was optimized based on good bioadhesive strength (326.96±0.99 N/M2) and sustained in vitro drug release (95.81% ± 3.21% for 8 hr), ex vivo permeation (96.59% ± 3.69% for 8 hr).
Article Information
24
706-716
860KB
1263
English
IJPSR
P.K. Khobragade*, P.K. Puranik, S.D. Pol, R.G. Palasakar and B.A. Patil
Pharmaceutics Department, Government College of Pharmacy, Vedant Road, Osmanpura Aurangabad- 431005, Maharashtra, India
pkkprajakta89@gmail.com
23 October, 2012
06 December, 2012
25 January, 2013
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(2).706-16
01 February, 2013
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