FORMULATION AND EVALUATION OF CO-CRYSTALS OF POORLY WATER SOLUBLE DRUGAbstract
The present study is an attempt to formulate and evaluate cocrystals of poorly water soluble drug Darunavir by cooling crystallization method using succinic acid as coformer. Cooling crystallization method used to prepare the cocrystals of darunavir with succinic acid. The prepared cocrystals were characterized by Microscopic characters, Product yield, Surface morphology. (SEM), Differential scanning calorimetry, X-ray diffraction, Fourier Transform Infrared Spectroscopy, Micromeretic properties, Dissolution study of cocrystals, stability studies, Thus, cocrystals using water soluble polymer like Succinic acid can be prepared using cooling crystallization method for a poorly water soluble drug such as Darunavir.
Shubhangi A. Bagde *, Kanchan P. Upadhye, Gauri R. Dixit and Suparna S. Bakhle
Department of Pharmaceutics, Priyadarshani J. L. College of pharmacy, Electronic zone, MIDC Hingna road, Nagpur, Maharashtra, India.
30 June, 2016
03 September, 2016
13 September, 2016
01 December, 2016