FORMULATION AND EVALUATION OF DERMA HEAL CREAM AGAINST WOUND AND BURN HEALING ACTIVITY IN STREPTOZOTOCIN-INDUCED DIABETIC WISTAR ALBINO RATAbstract
Delayed wound healing is producing a high economic burden on the society and is generally associated with Diabetes mellitus or a related complication thus needs safe treatment like herbal formulation. Dermas heal cream (an anti-diabetic ayurvedic formulation) was evaluated for wound and burn healing potential in normal and diabetic rats. The effect of Derma heal cream on wound healing has been studied in diabetic and normal animals and compared with standard using the excision wound model. Diabetes was induced by a single dose of Streptozotocin 55 mg/kg i.p. Rats with blood glucose levels >250 mg/dl are considered as diabetic and included in the study for incision, excision and burn heal model. Rats treated with derma heal cream (DHC) at doses 1000 mg/kg dose per day were applied topically in the excision wound model, treated DHC shows significant effect reduction in period of 21st day and wound area is (5 ± 1.15 mm)and normal group wound area is (1.66 ± 2.12 mm) as compared to diabetic control group (25 ± 5.90 mm). Dermas heal cream in the incision wound model shows significantly reduced on 14th day treatment period the wound concentration in normal group (7 ± 1.7 mm) and DHC group (6.33 ± 1.15 mm) as compared to diabetic control group (25.10 ± 3.40 mm). Derma heal cream a showing healing of the open, closed and burn wound in negative group animals along with diabetic animals as compared to diabetic control group.
R. G. Khan *, A. Jumaan and A. Taliab
Department of Pharmacology and Toxicology, Dubai Institute for Environmental Research and Laboratory Analysis, Dubai, UAE.
09 March 2019
07 January 2020
20 February 2020
01 March 2020