FORMULATION AND EVALUATION OF DOMPERIDONE FAST DISSOLVING TABLETS USING PLANTAGO OVATA MUCILAGEAbstract
The present investigation deals with development of fast dissolving tablets of Domperidone to produce the intended benefits. Domperidone is an antiemetic and a prokinetic medicine. Domperidone is water insoluble drug with problems of variable bioavailability and bio-inequivalence. As precision of dosing and patient’s compliance become important prerequisite for quick relief from emesis, there is a need to develop a formulation for this drug which overcomes problems such as difficulty in swallowing, inconvenience in administration while traveling and better compliance. Hence, the present research work was held to develop a fast dissolving tablet of domperidone using Plantago ovata mucilage as a natural super disintegrant. The tablets were prepared by Direct Compression using microcrystalline cellulose as a directly compressible vehicle. Tablets were evaluated for their physicochemical properties and In-vitro dissolution study. The evaluation studies were performed such as Weight Variation, Thickness, Hardness, Disintegrating Time, Wetting Time, and In-vitro Drug release study. The Disintegration time of Fast Dissolving tablets were increased by the addition of concentration of Super disintegrants.
Ravi Subhashini* and D. Ramesh Reddy
Department of Pharmaceutics, Vishwa Bharathi College of Pharmaceutical Sciences, Perecherla (V) (M),Guntur (Dt)-522009, Andhra Pradesh, India
26 April, 2013
14 August, 2013
28 August, 2013
01 September, 2013