FORMULATION AND EVALUATION OF DORZOLAMIDE SPANLASTICSAbstract
Dorzolamide is commonly used to treat glaucoma, damage in the eye often caused by abnormally high pressure in the eye. It is one of the carbonic anhydrase inhibitors which is effective in decreasing intraocular pressure by decreasing the production of the aqueous humor. The main objective of the study was to entrap dorzolamide in a novel nanovesicular carrier system (spanlastics) to ensure sustained and intravitreal delivery in eye to overcome the problem of frequent dosing. The Dorzolamide spanlastics prepared were checked on three factors, i.e., the ratio of Span 60: Tween 80, sonication time and stirring speed. The formulation was evaluated for various parameters such as the size of nano-vesicles, Polydispersity index, zeta potential, and entrapment efficiency. The mechanism involved destabilization of lipid bilayer of the cell, which in turn facilitates diffusion of a drug within the cell and increased bio-availability. Hence, Dorzolamide spanlastics may prove to be an effective formulation in glaucoma.
A. Sharma, S. Pahwa *, S. Bhati and P. Kudeshia
Lloyd Institute of Management and Technology (Pharm.), Greater Noida, Uttar Pradesh, India.
17 August 2019
17 January 2020
05 March 2020
01 August 2020