FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF AMLODIPINE BESYLATE BY USING HIBISCUS ROSA – SINENSIS MUCILAGE AND MODIFIED GUM KARAYAAbstract
In the present study, natural gums (Hibiscus rosa – sinensis mucilage and Modified gum karaya) was investigated as superdisintegrants for use in fast dissolving tablet formulations containing amlodipine besylate. Fast dissolving tablets of amlodipine besylate was formulated using different concentrations (2, 4, 6, 8, 10) of natural superdisintegrant viz; Hibiscus Rosa – sinensis mucilage and modified gum karaya. Prepared tablets were evaluated for thickness, hardness, friability, uniformity of weight, disintegration time, wetting time and dissolution study. The formulated tablets had good appearance and better drug release properties. The best formulation of Hibiscus rosa – sinensis mucilage (FHR5) and modified gum karaya (FMGK5) shows shorter disintegration time and shows 100% release is selected as optimized formulation. Hence, the present study revealed that this natural superdisintegrants (Hibiscus rosa – sinensis mucilage and modified gum karaya) showed better disintegrating property than the most widely used synthetic superdisintegrants. Studies showed that naturally obtained polymers are more beneficial without any side effects. Optimized formulation was subjected to stability studies as per ICH guidelines and it insignificant change in hardness, disintegration time and in vitro drug release.
Sudheshnababu Sukhavasi* and V. Sai Kishore
Department of Pharmaceutics, Bapatla College of Pharmacy, Bapatla-522101, Andhra Pradesh, India
16 June, 2012
18 August, 2012
26 September, 2012
01 October, 2012