FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF GRANISETRON HYDROCHLORIDE BY DRY GRNULATION METHODAbstract
The aim of work is to characterization and evaluation of fast dissolving tablet of Granisetron hydrochloride using three superdisintegrants like crosscarmellose sodium, crosspovidone and sodium starch glycolate. FTIR studies revealed that there was no physico-chemical interaction between granisetron hydrochloride and other excipients. The tablets were prepared by dry granulation method and all had the same amount of ingredients except, the superdisintegrant level. The prepared batches of tablets were evaluated for uniformity of weight, thickness, hardness, friability, disintegration time and in-vitro dissolution study. Tablet containing crosspovidone showed excellent disintegration time and drug release as compared to other formulations.
Basawaraj S. Patil *, N. G. Raghavendra Rao and Upendra Kulkarni
Professor, Department of Pharmaceutics, R.M.E S’s College of Pharmacy, Old Jewargi road, Gulbarga, Karnataka, India
21 February, 2011
21 March, 2011
07 April, 2011
01 May, 2011