FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF SUMATRIPTAN SUCCINATE
AbstractIn the present study an attempt has been made to prepare fast dissolving tablets of Sumatriptan Succinate to improve dissolution rate of the drug in oral cavity & hence better patient’s compliance & effective therapy. Sumatriptan Succinate is a 5-HT1D (5-hydroxy tryptamine 1D) receptor agonist, used in the treatment of migraine and cluster headache. It has low bioavailability due to its first pass metabolism. Hence the main objective of the study was to formulate fast dissolving tablets of Sumatriptan succinate to achieve a better dissolution rate and further improving the bioavailability of the drug. Fast dissolving Sumatriptan succinate was prepared using superdisintegrants Crospovidone, Croscarmellose Sodium, and Preglatinised Starch using the direct compression method. The tablets prepared were evaluated for Thickness, Uniformity of weight, Drug content, Hardness, Friability, Wetting time, in vitro and in vivo disintegration time, in vitro drug release. The formulation F3 containing Crospovidone (8%) was found to give the best result since it showed enhanced dissolution, which leads to improved bioavailability, improved effectiveness and hence better patient compliance
Article Information
37
1912-1917
578KB
1374
English
IJPSR
Shailendra Singh Bisht*, Himanshu Chaurasia , Sugandha Varshney , Reena and Deepti Kotiyal
School of Pharmaceutical Sciences, Shobhit University, Meerut, Uttar Pradesh, India
shailbishtpharma30@gmail.com
17 January, 2013
04 March, 2013
26 April, 2013
http://dx.doi.org/10.13040/IJPSR.0975-8232.4(5).1912-17
01 May, 2013
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