FORMULATION AND EVALUATION OF FLOATING MICROSPHERE H2 RECEPTOR BLOCKER RANITIDINE HCl BY IONIC GELATION METHODAbstract
The present study involves preparation of floating microspheres of Ranitidine Hydrochloride with Sodium alginate, Guargum and Xanthan using ionic gelation method. Floating microspheres were aimed to achieve an extended retention in the upper gastrointestinal tract, which may result in enhanced absorption and thereby improved bioavailability. The formulations were evaluated for FTIR, drug loading, % entrapment, particle size, SEM, buoyancy, dissolution study and the drug release kinetics. The enhanced floatability of the formulation and its retention in GIT may attribute for the increased bioavailability and decrease in frequency of administration. Comparison of three polymers revealed HPMC to be a suitable candidate for sustained release.
Ajaykumar Tiwari*, Gaurang Patel and Nirav Rabadia
Department of Pharmaceutics, School of Pharmaceutical Science, Jaipur National University, Jaipur, Rajasthan, India
21 April, 2012
27 May, 2012
27 July, 2012
01 August, 2012