FORMULATION AND EVALUATION OF FLOATING TABLET OF METOPROLOL SUCCINATE WITH SYNTHETIC SUPERDISINTEGRANTAbstract
The present work was designed to formulate floating tablet of Metoprolol Succinate with synthetic superdisintegrant as swelling agent. Various formulations of Metoprolol Succinate were prepared by direct compression method using the different concentrations of superdisintegrant ranging from 10% to 15%. The selected batches were evaluated for various parameter like weight variation, thickness, diameter, friability, floating lag time, duration of floating, water uptake, content uniformity, in-vitro drug release and in-vitro drug release kinetics. Formulations with Crosspovidone had showed better results than the Kyron T-314. The data obtained from the in-vitro dissolution studies of optimized batch F5 was fitted in different models viz. zero order, first order, Korsemeyer-Peppas model, Higuchi model and Hixon-Crowell model. Drug release mechanism was found to be First order from optimized formulation. Further for getting the type of release mechanism the data was fitted as per the Korsemeyer-Peppas equation. The exponent value n was found in between 0.45 to 0.89. It indicates that the release of Metoprolol Succinate from developed floating tablets followed non-Fickian transport mechanism.
Pankaj Kumar Yadav* and Himansu Chopra
Faculty of Pharmacy, GRD (PG) IMT, 214-Rajpur Road, Dehradun, 248009, Uttarakhand, India
09 November, 2013
14 December, 2013
23 March, 2014