FORMULATION AND EVALUATION OF FLOATING TABLETS OF OFLOXACINAbstract
Ofloxacin is a synthetic chemotherapeutic antibiotic of the fluoroquinolone drug class considered to be a second-generation fluoroquinolone. Gastric emptying of dosage forms is an extremely variable process and ability to prolong and control the emptying time is a valuable asset for dosage forms, which reside in the stomach for a longer period of time than conventional dosage forms. Several difficulties are faced in designing controlled release systems for better absorption and enhanced bioavailability. To overcome the problem of conventional dosageforms ofloxacin effervescent floating tablets were developed in six different formulations (F1 to F6) by employing different grades of polymers and effervescent agent sodium bicarbonate. The formulations were evaluated for various physical parameters, buoyancy studies, dissolution parameters and drug release mechanisms. F6 formulation showed good physical parameters and gave slow and maximum drug release of ofloxacin spread over 24 hours and showed maximum similarity with marketed product in dissolution profile. Different kinetic models were applied to drug release data in order to evaluate release mechanisms and kinetics.
Saigeethika S.*, Gautam Singhvi and Ramanjaneyulu
Vishnu Institute of Pharmaceutical Education & Research, Narsapur, Medak-502313, Andhra Pradesh, India
15 July, 2012
03 September, 2012
29 October, 2012