FORMULATION AND EVALUATION OF GASTRO RETENTIVE MATRIX TABLETS OF ATENOLOL USING MELT GRANULATION TECHNIQUEAbstract
The main objective of this present work was to develop and evaluate matrix tablets of Atenolol by melt granulation technique and compare the drug release between bess wax and glyceryl monostearate (GMS). Polymers like HPMC K 4 M, HPMC K 100 M, bees wax, glyceryl monostearate and ethyl cellulose were incorporated in the formulation. Formulations were prepared by keeping the HPMC and ethyl cellulose at constant ratio. Bees wax and glyceryl monostearate (GMS) were used in different ratios. FTIR studies indicate that there is no interaction between drug and excipients. Developed tablets were evaluated for weight variation, friability, hardness, thickness, drug content, swelling index and drug release profiles. The dissolution studies showed that drug release was better in the formulations where glyceryl monostearate (GMS) is higher than the bees wax. Thus, it was concluded that HPMC K 4 M, HPMC K 100 M along with Bees wax and Glyceryl monostearate can be successfully used in the formulation of Atenolol sustained release gastro retentive floating drug delivery system
Sarada Anepu *, Lohithasu Duppala , Nikhil J. and Janaki Devi S.
A.U. College of Pharmaceutical Sciences, Andhra University, Visakhapatnam, Andhra Pradesh, India
02 September, 2015
02 November, 2015
12 December, 2015
01 March, 2016