FORMULATION AND EVALUATION OF HYDRALAZINE HYDROCHLORIDE MOUTH DISSOLVING TABLET FOR THE MANAGEMENT OF ECLAMPSIA AND PRE-ECLAMPSIAAbstract
Eclampsia and Pre-Eclampsia is an acute and life-threatening complication during pregnancy. Hydralazine hydrochloride is one of the drugs of choice in treating this condition. The purpose of the present research work was to formulate the Mouth Dissolving Tablets by using different methods and provide a suitable patient convenience dosage form to enhance the bioavailability and provide quick onset of action. Formulation of MDTs of Hydralazine hydrochloride were prepared by using various superdisintegrants like cross-povidone, cross-carmellose sodium and sodium starch glycolate by direct compression method and camphor as an excipient by sublimation technique. Among all the formulations F9 and SF9 showed effective percentage of drug release at 12 minutes indicating faster and maximum absorption at the site of administration.
S. M. Kumar* and R. S. Ganapathy
Faculty of Pharmacy, Karpagam University, Karpagam Academy of Higher Education, Coimbatore, Tamil Nadu, India.
09 June, 2017
21 August, 2017
29 August, 2017
01 March, 2018