FORMULATION AND EVALUATION OF HYDROTROPIC SOLID DISPERSION OF ELUXADOLINEAbstract
In the present research, newly developed hydrotropic solid dispersion technique utilizing the use of aqueous solvent was developed, to avoid the utilization of organic solvent and all together declining their toxicity. This technology was employ intended for preparing the dispersion of Eluxadoline by using new hydrotropic agent sodium caprylate with using different ratio. Prepared formulations were evaluated by Solubility study, Fourier transforms infrared spectroscopy, X-Ray Diffractometry, Drug content analysis, and in-vitro drug release study. Based on the evaluation of hydrotropic solid dispersion concluded that the concept or technology of hydrotropic solid dispersion method is a novel, nontoxic and as well cost-eﬀective technique for the rationale of enhancing the aqueous solubility of substance and bioavailability of poorly water-soluble drugs. The improvement within solubility and dissolution of Eluxadoline is a clear sign. It can be able to use in the future for more poorly water-soluble drugs to enhance solubility and also which having low bioavailability is a major problem.
M. Dhere *, A. Majumdar and N. Malviya
Smriti College of Pharmaceutical Education, Indore, Madhya Pradesh, India.
20 March 2019
11 June 2019
17 July 2019
01 December 2019