FORMULATION AND EVALUATION OF IMMEDIATE RELEASE TABLETS OF PIOGLITAZONE HYDROCHLORIDE BY EMPLOYING MODIFIED SUPERDISINTEGRANTSAbstract
The aim and objective of the present work is to design and develop immediate release tablets of pioglitazone hydrochloride to improve the patient compliance and desired bioavailability by selected delivery system by following immediate release mechanism. In the present investigation, super disintegrants used in the combination of 1:1 ratio were modified using co-processed technology with the solvents like acetone and methanol using solvent evaporation technique. The dissolution rate of the drug was significantly increased which reaches closer to the dissolution profile of marketed product. This was due to an increase in surface area of drug available for dissolution. The physical modification of super-disintegrants using co processing technique and selection of processed material with particle size specificity made the drugs to possess required characteristics as fast dispersible. The pre compression and post compression properties are determined as per the procedure prescribed. The drug release studies and kinetics indicate that the prepared tablets with co-processed superdisintegrants were best at its release in the entire tract of GIT due to their change in bio pharmaceutical property like dissolution. Optimized formulations were selected for stability concern and in-vivo performance. The best formulations retain its properties within the stability period of 3 months. The in-vivo properties evaluated confirmed the approach of good bioavailability by the drug with the help of the design of drug into immediate release product.
B. V. Ramana *and T. E. G. K. Murthy
Dr. K. V. Subba Reddy Institute of Pharmacy, Kurnool Rayalaseema University, Kurnool, Andhra Pradesh, India.
05 September, 2017
06 December, 2017
25 December, 2017
01 June, 2018