FORMULATION AND EVALUATION OF INDAPAMIDE SUSTAINED RELEASE MATRIX TABLETS
AbstractThe study was undertaken with an aim to formulate anti-hypertensive agents as sustained release matrix tablets. The literature review showed that Indapamide is an anti hypertensive / diuretics in SR dosage form 50% of drug is released between 5-14hrs and 20-80ng/ml blood level is obtained for 24 hrs and SR form permits uniform and constant blood level after absorption of galenic form by oral route up to now it is available as IR with an dose of 2.5mg/day which results in considerable blood peaks, it is formulated as SR form to avoid and maintain constant blood level and to maintain better theraupetic index. In the present study, HPMC was found to play a great role in controlling release of drug Indapamide from the matrix system. Incorporation of HPMC K 100 M CR as release controlling polymer in extra granular fraction was found helpful in restoring the original and still closer release profile.
Article Information
36
1255-1259
537
1321
English
IJPSR
V. Rajesh Babu* and Syeda Rana Nikhat
Department of Pharmaceutics, MESCO College of Pharmacy, Hyderabad, Telangana, India.
rajeshbabuvemula@gmail.com
23 August, 2016
18 October, 2016
28 November, 2016
10.13040/IJPSR.0975-8232.8(3).1255-59
01 March, 2017
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