FORMULATION AND EVALUATION OF LOSARTAN POTASSIUM BI-LAYER BUCCAL TABLET USING MUCOADHESIVE POLYMERAbstract
In the present study, an attempt was made to design and evaluate mucoadhesive bilayer tablet of losartan potassium (angiotensin II receptor antagonist), in order to overcome bioavailability problems, to reduce dose dependent side effects and frequency of administration. The losartan potassium mucoadhesive buccal tablet were prepared by wet granulation method using chitosan as a mucoadhesive polymer to prolong the drug release and to avoid first pass metabolism. The prepared Mucoadhesive buccal tablets were evaluated by pre and post compression parameter. Precompression test like bulk density, tap density, angle of repose and post compression test include thickness, hardness, friability, weight variation, drug content, disintegration time, wetting time, surface pH, in-vitro drug release and ex-vivo mucoadhesive time. The drug excipients compatability was evaluated by DSC studies.
S. Z. Chemate and S. Bothe Priyanka *
Department of Pharmaceutics, PDVVPF’S College of Pharmacy, Vilad Ghat, Ahmednagar, Maharashtra, India
06 November, 2016
12 January, 2017
02 February, 2017
01 June, 2017