FORMULATION AND EVALUATION OF MATRIX DIFFUSION CONTROLLED TRANSDERMAL DRUG DELIVERY OF HYDRALAZINE HYDROCHLORIDE FOR THE TREATMENT OF HYPERTENSIONAbstract
In the present study novel matrix diffusion controlled transdermal patches of Hydralazine hydrochloride, a hypertensive drug to ensure satisfactory drug release were successfully prepared by solvent casting method with optimization of suitable polymeric blend of Eudragit L100 (EL-100), ethyl cellulose (EC), polyvinylpyrrolidone (PVP), polyvinyl alcohol (PVA), carbopol, hydroxypropyl cellulose (HPC) to achieve sustained release pattern within the therapeutic range. N-dibutyl phthalate (n-DB) used as a plasticizer and oleic acid used as a permeation enhancer. Different batches of transdermal patches were prepared by varying different polymers with the difference in ratio. Prepared transdermal patches from each batch, gave release profile for over 12 h. Fourier Transform Infrared analysis shows no interaction between drugs and polymers. Cumulative amount of drug release in 12 h from all the prepared formulation were found to be in following order: F1> F2> F3> F4> F9> F8> F7> F10> F5.F6. Combination of Eudragit L100 and PVP (F1 and F2) and Ethylcellulose and PVP (F3 and F4) exhibited good characteristics for sustained release action.