FORMULATION AND EVALUATION OF MEDICATED ORAL JELLY OF TRAZADONE HYDROCHLORIDEAbstract
The objectives of the present investigation were to formulate and evaluate of Medicated oral jelly containing Trazadone HCl for the treatment of depression. Many psychotic patients are medicinal phobic who are afraid of taking medicine, so this preparation is most beneficial over that type of fear. Trazadone HCl antidepressant drugs incorporate in jelly and give to those patients; in this way, we could administer medicine to them without bringing this to their attention. Jellies are prepared by heating and congealing methods by dispersing gelling agents in water and evaluated for their physicochemical parameters like appearance, stickiness, pH, viscosity, Spreadability, stability studies, drug release, and content uniformity. All batches (F1-F8) of medicated jelly showed acceptable and comparable appearance, pH, viscosity, Spreadability, stability studies, drug release, and content uniformity. The viscosity range was found to be 53305 to 61731cps. The drug content of F1 to F8 formulations was found to be in the range of 88.42 to 98.95%. F7 batch prepared with gelatin + xanthan gum combination shows 98.95%. drug release.
V. S. Kadam *, J. Kendre, G. R. Shendarkar and S. S. Kadam
Department of Pharmaceutics, Kandhar College of Pharmacy, Kandhar, Nanded, Maharashtra, India.
10 December 2019
28 March 2020
31 March 2020
01 December 2020