FORMULATION AND EVALUATION OF MICROCAPSULES OF TRIHEXYPHENIDYLE HYDROCHLORIDE BY SOLVENT EVAPORATION METHOD.Abstract
Trihexyphenidyle is a lipophilic antiparkinsonian drug with short half life. Practically slightly soluble in water makes formulation and delivery difficult. By formulating the same in the microcapsule by using biodegradable polymer Eudrajit L 100 and S 100, the half life and solubility can be altered and hence drug release pattern. Trihexyphenidyle microcapsules were prepared by solvent evaporation method by using different drug-polymer ratio (1:2, 1:3, 1:4, 1:5). Prepared microcapsules were evaluated for the particle size, percentage yield, incorporation efficiency, flow property and in vitro drug release at pH 6.8 for 12 hours. From the result we can conclude that as the concentration of polymer increases, it affects the particle size, percentage yield and drug release of micro capsules. The formulation F2 shows the excellent flow properties, particle size, percentage yield (91.24%), incorporation efficiency (94.59%) and percentage drug release (95.88%) for a period of 12 hrs. Results of the present study indicate that Trihexyphenidyle microcapsules can be successfully designed to develop sustained drug delivery, that reduces the dosing frequency and their by we can increase the patient compliance.