FORMULATION AND EVALUATION OF MUCOADHESIVE MATRIX TABLET OF ACYCLOVIRAbstract
The binding capacity of mucoadhesive polymers with gastric mucin prolongs the gastric residence time, increasing bioavailability. In the present research work, an attempt was made to formulate and evaluate sustain release mucoadhesive matrix tablet of Acyclovir. In the present work, an effort has been made to evaluate the effect of mucoadhesive polymers on the release characteristics of mucoadhesive matrix tablets of Acyclovir. Matrix tablets were prepared by wet granulation method using different types and levels of polymers viz. Chitosan and HPMC K4M. Tablets were evaluated for thickness, friability, hardness, uniformity of weight, the content of active ingredients, mucoadhesive strength, and in-vitro dissolution studies. The studies indicated that the drug release can be modulated by varying the concentrations of polymers. It was observed from the optimization studies that the F3 formulation has exhibited the best release profile of the drug and can sustain the drug release for 8 h with optimum mucoadhesive strength.
Ashwini Madgulkar, Mangesh Bhalekar, Tejinder Kaur and Nisha Thange *
Department of Pharmaceutics, AISSMS College of Pharmacy, Near RTO, Kennedy Road, Pune, Maharashtra, India.
03 January 2022
08 July 2022
17 August 2022
01 September 2022