FORMULATION AND EVALUATION OF NIFEDIPINE LOADED CHITOSAN MICROSPHERS FOR MUCOADHESIVE DRUG DELIVERYAbstract
Nifedipine loaded mcoadhesive micropshres were prepared by o/w/o emulsification cross linking method using natural polymer chitosan. Microsphres with particle size range b/n 50-300 µm were obtained by this method. The prepared microspheres were evaluated for its drug loading, surface properties, in-vitro release profile. The diffusion and permeation characteristic of the drug is studied by using cellophane membrane and excised porcine intestinal mucosa respectively. The mucoadhesion properties of the microsphers were determined by using modified USP disintegration test apparatus model. In vivo animal studies were studies using rabbit model indicated a controlled blood level profile in comparison with pure nifedipine. IR studies indicated no appreciable drug excipient interaction.
Preethi Sudheer * and Ramakrishna Shabaraya A.
Associate Professor, Dept. of Pharmaceutics, Krupanidhi College of Pharmacy Bangalore -35, India.
29 April, 2014
30 September, 2014
15 October, 2014
01 November, 2014