FORMULATION AND EVALUATION OF OLANZAPINE AS “ORODISPERSIBLE DRUG DELIVERY SYSTEM” BY USING BETA CYCLODEXTRIN AND SUPER DISINTEGRANTAbstract
As the psychotic, pediatric and geriatric patients are unable to swallow the medicine mouth dissolving drug delivery systems are designed for rapid dissolution and absorption of drug in the mouth within minutes without the need of water or chewing. Olanzapine is water insoluble drug hence to make it solubilize it is formulated as drug- polymer inclusion complex by using. The aim of the present study was to formulate olanzapine orodispersible tablets by using β-cyclodextrin and superdisintegrants to enhance the solubility of the drug. The drug, polymer and inclusion complex were investigated for drug interactions, complex formation and change in crystallinity by using infrared, differential scanning calorimetry, x-ray diffraction and the tablets were developed by using the direct compression and were investigated for in-vitro dissolution behavior and drug content. β-cyclodextrin (1:1M) can be used to enhance the solubility and dissolution rate of the drug. AC-DC-SOL (crosscarmellose sodium) as a super disintegrant shows faster release than both control and formulation by other superdisintegrants for quick release of the drug from the tablet.
I. Sarath Chandiran, V. Narayanan* and S. Sushma
Gokula Krishna College of Pharmacy, Sullurpet, Nellore, Andhra Pradesh, India
26 January, 2011
11 March, 2011
17 April, 2011
01 May, 2011