FORMULATION AND EVALUATION OF ONCE DAILY MATRIX TABLETS OF METOPROLOL SUCCINATE USING HYDROXYPROPYL METHYL CELLULOSE BY WET GRANULATION TECHNIQUEAbstract
The aim of the current study was to develop once-daily sustained-release matrix tablets of metoprolol succinate, Selective β1– blocker used in cardiovascular diseases. The tablets were prepared by the wet granulation method. Ethanolic solutions of ethylcellulose (EC), polyvinylpyrrolidone K30 were used as granulating agents along with hydrophilic matrix polymer hydroxypropyl methylcellulose (HPMC K100M). The granules were evaluated for angle of repose, bulk density, compressibility index and drug content. The tablets were subjected to thickness, diameter, weight variation test, drug content, hardness, friability, and in vitro release studies. The granules showed satisfactory flow properties, compressibility, and drug content. All the tablet formulations showed acceptable pharmacotechnical properties and complied with in-house specifications for tested parameters. The results of dissolution studies indicated that batch AH3 (Drug-to-HPMC K100M, ethyl cellulose solution (4%W/V, as granulating agent) could extend the drug release up to 24 hours. Batch AH3 showed highest f2 value 84.95 and MDT 8.9 hrs similar to that of reference product. The dissolution data were subjected to model fitting analysis and best fitted model was Higuchi model. All the formulations (except batch AH3) exhibited diffusion-dominated drug release. The mechanism of drug release from batch AH3 was diffusion coupled with erosion.
Kunal Parmar*, rajeshvari suthar, Dhaval Katharotiya, Niraj Soni, Nehal Amin, Rajesh Parikh, Mukesh gohel
Astral Pharmaceutical Industries, Vadodara, Gujarat,, India
29 May, 2011
26 August, 2011
28 August, 2011
01 September, 2011