FORMULATION AND EVALUATION OF ORODISPERSIBLE TABLETS OF SALBUTAMOL SULPHATEAbstract
Objective of the present work is to develop orodispersible tablets of Salbutamol sulphate to improve bioavailability, disintegration time, dissolution efficacy and patient compliance. Orodispersible tablets are the fast growing and highly accepted drug delivery system in now days mainly to improve patient compliance. Orodispersible tablets have number of advantages over conventional dosage forms, because of that Orodispersible tablets have emerged as an alternative to conventional dosage forms. Orodispersible tablets dissolve or disintegrates instantly on the patient tongue or buccal mucosa. Orodispersible tablets of solbutamol sulphate were prepared using superdisintegrants, ac di sol, sod.cmc, alginic acid, chitosan, mcc, as diluents by direct compression method. Twelve formulations were prepared using the superdisintegrants at lower, intermediate & higher concentration. Mannitol is used to enhance the organoleptic properties of tablets. Tablets were evaluated for uniformity of weight, hardness, friability, water absorption ratio, dispersion time, disintegration time and in vitro drug release. All the formulations showed disintegration time less than 33mins and drug release by dissolution (100% at the end of 10 mins).
D.K. Gupta*, R.D. Sharma, Ritu Gupta , S. Tyagi , K.K. Sharma and Anurag Choudhary
Assistant Professor, Department of Pharmacy, Faculty of Pharmacy, Bharat Institute of Technology, Meerut, Uttar Pradesh, India
02 May, 2012
02 June, 2012
27 July, 2012
01 August, 2012