FORMULATION AND EVALUATION OF POLYHERBAL GEL FOR ANTI – INFLAMMATORY ACTIVITYAbstract
In the present study, three medicinal plants Cynodon dactylon (L.) Pers, Cassia tora Linn. and Cassia alata Linn having significant anti-inflammatory potential were selected to be formulated as polyherbal gels. The gels were prepared using the dried methanolic extract of Cassia tora Linn, Cassia alata Linn and Cynodon dactylon (L.) Pers. Polyherbal gel formulations were evaluated for its pH, appearance and homogeneity, viscosity, spreadability and skin irritation studies. Assessment of Anti-inflammatory activity was done by carrageenan induced rat paw edema and formalin- induced rat paw edema. Individual and polyherbal gel of Cassia alata Linn,Cassia tora Linn. and Cynodon dactylon (L.) Pers were found to possess anti-inflammatory effect in acute and chronic models. Polyherbal gel also showed synergistic effect as compared to individual gels which can be useful for the treatment of local inflammation.
Gouri Dixit*, Ganesh Misal, Vijay Gulkari and Kanchan Upadhye
Department of Pharmaceutics, J. L. Chaturvedi College of Pharmacy, Electronic zone, MIDC, Hingna road, Nagpur-440016, Maharashtra, India
09 November, 2012
12 January, 2013
15 February, 2013
01 March, 2013