FORMULATION AND EVALUATION OF SATRANIDAZOLE BY SELF EMULSIFYING DRUG DELIVERY SYSTEM

Background: Satranidazole is a class II drug per biopharmaceutical classification systems with poor aqueous solubility and antiprotozoal and anti-bacterial properties. Aim: Therefore, the purpose of the present study was to enhance the solubility of Satranidazole using a self-emulsified drug delivery system (SEDDS). Methods: SEDDS was prepared using Satranidazole (10 mg) and dissolved in the oil phase, i.e., rice bran oil and GMO (1:9). The co-surfactant, propionic acid, was added to the oil phase, and then Tween 80 was added with continuous stirring. The mixture was allowed to homogenize at 40 °C for 24 h and was stored in a stoppered glass vial until further evaluation. The total amount of the mixture was kept constant at 0.37 ml to be filled in size 2 capsules for dissolution study. Physico-Chemical Evaluation: Four SEDDS formulations were prepared (F-1 to F-4) and evaluated for droplet size analysis, stability studies, zeta potential, drug content and in-vitro drug release. Results: Based on self-emulsification time & dispersibility, droplet size analysis, drug content and in vitro drug release, S-1formulation was selected as an optimized formulation that showed a maximum drug release of 98.15 ± 1.84 % in 45 min. Conclusion: Hence SEDDS formulations can be a potential alternative to available traditional oral drug delivery systems of Satranidazole to improve its solubility.