FORMULATION AND EVALUATION OF SOLID LIPID NANOPARTICLE GEL FOR TOPICAL DELIVERY OF CLOBETASOL PROPIONATE TO ENHANCE ITS PERMEATION USING SILK SERICINAS PERMEATION ENHANCER

The objective of this present work was to develop Solid Lipid Nanoparticle (SLN) gel for topical delivery of clobetasol propionate to enhance its permeation using silk sericin as a permeation enhancer. The proposed Clobetasol propionate gel loaded with solid lipid nanoparticle was prepared by solvent injection method. The effects of different strengths of lipid on the particle size, zeta potential, drug entrapment and release, and drug excipient interactions and the thermal behavior were evaluated. The final gel formulations were obtained by adding carbopol as a gelling agent and sericin a natural silk protein as a permeation enhancer and tested by an in-vitro gelling test. Prepared gel was evaluated for viscosity, pH, and in-vitro permeation properties. This study showed that the combination of carbopol with silk sericin produced the most promising gel formulation for topical application in the treatment of psoriasis. In this study, it was demonstrated that silk sericin-based gel, blended with solid lipid nanoparticle, could be produced with a cost-effective and industrially scalable technique. The outcome represents the starting point for the development of potential topical formulations suitable for the treatment of psoriasis.