FORMULATION AND EVALUATION OF SOLID SELF EMULSIFYING DRUG DELIVERY SYSTEM FOR DRUG MIRTAZAPINEAbstract
Objective: In the present dissertation work, the aim was to prepare self-emulsifying drug delivery systems (SEDDS) of mirtazapine to improve its solubility with a view to enhance its oral bioavailability. Methods: The prepared SEDDS was the concentrate of the drug, oil-Capmule MCM EP, surfactant tween 80 and PEG 400 as a co-surfactant. The optimized microemulsion was converted into solid form by adsorption technique by using as Neusiline US2 solid carrier. The formulation was evaluated for various tests such as solubility, drug content, emulsification time, phase separation study, dispersibility test, droplet size analysis and PDI determination and zeta potential and in-vitro release study, and in-vitro permeation study. Results: The optimized formulation F5 showed drug release (96.97 ± 1.89), droplet size (153), Zeta potential (-30mv). All formulations of mirtazapine SEDDS were showed faster dissolution than plain drug, mean bioavailability of mirtazapine increase in respect to the plain drug. The F5 can be further used for the preparation of various solid SEDDS. In conclusion, self-emulsifying drug delivery system has become promising tool to overcome shortcomings associated with conventional delivery.
P. R. Shelake *, R. R. Shah, V. V. Nalawade and P. P. Majalekar
Department of Pharmaceutics, Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra, India.
18 January 2019
11 July 2019
26 December 2019
01 February 2020