FORMULATION AND EVALUATION OF SUSTAIN RELEASE MATRIX TABLET OF FLUVOXAMINE MALEATE USING MORINGA OLEIFERA GUMAbstract
Fluvoxamine Maleate, an oral serotonin reuptake inhibitor, has been used widely for the treatment of anxiety. Sustained-release matrix-type drug delivery system has advantages over conventional modes of drug administration, enhancing drug bioavailability as it avoids the first-pass metabolism and improves patient compliance. Optimization of the formulation was performed by varying the concentration of natural polymer Moringa oleifera gum and HPMC K100, i.e., releases retarding polymers. Sustain release matrix tablets were formulated, and the drug release profiles of formulations F3 and F6 were found to be 93.8008% and 96.94108%, respectively.
P. D. Deore, S. A. Katti * and S. S. Sonawane
Department of Pharmaceutical Quality Assurance, Mahatma Gandhi Vidyamandir’s Pharmacy College, Nashik, Maharashtra, India.
23 July 2020
10 December 2020
15 May 2021
01 July 2021