FORMULATION AND EVALUATION OF SUSTAINED-RELEASE TABLET HAVING GENISTEINAbstract
Genistein is phytoestrogens that function on estrogen receptors through a receptor-dependent mechanism. Genistein is commonly used to alleviate menopause symptoms, lower breast cancer risk, protect against prostate problems, improve bone health and lower the risk of heart disease. This research aims to create Genistein oral tablets with a long release time. In a rotary tableting machine, tablets were made using the Wet Granulation technique. In-vitro release studies were conducted using a 1% SLS aqueous solution in a Paddle apparatus (USP Type-II apparatus) for 120 min at 37 + -05 °C and 100 RPM. The formulation containing Methocel K 100 LV and K4M was found to be the best based on dissolution results. The formulations were tested for stability according to ICH guidelines and were found to be stable during the sample. Flow properties, Carr and Hausner indexes, hardness, friability, disintegration time and drug release profile were among the parameters tested on powder, granules and tablets. In addition, a quick and reliable HPLC analytical method for Genistein has been developed.
Heena Farooqui * and Prashant Upadhyay
School of Pharmaceutical Sciences, Faculty of Pharmacy, IFTM University, Moradabad, Uttar Pradesh, India.
25 April 2021
08 June 2021
12 June 2021
01 February 2022