FORMULATION AND EVALUATION OF TIZANIDINE SUSTAINED RELEASE MATRIX TABLETS USING HYDROXY PROPYL METHY CELLULOSE
AbstractTizanidine is a muscle relaxant agent, with the half life of 2.5 hours and requires daily doses to maintain adequate plasma concentrations. The present study was undertaken to with an aim to formulation development and evaluation of Tizanidine hydrochloride sustained release tablets using hydrophilic polymer to sustain the action of Tizanidine. Different batches of Tizanidine hydrochloride were prepared based on preformulation studies using HPMC K100M HPMC K4M and HPMC K100 having different viscosities to calculate the sustained release properties. Tizanidine hydrochloride was analysed by using HPLC using wavelength 240 nm. Results of in-vitro study indicate that the trial formulation 5 having considerable sustaining property. From the discussion it is concluded that the trial formulation 5 had considerable in-vitro drug release. Trial formulation 5 can be taken as an ideal or optimized formulation of sustained release tablets for 12 hours release and it fulfils all the requirements for sustained.
Article Information
44
3237-3244
682KB
1511
English
IJPSR
Ankita Srivastava
Department of Pharmaceutical sciences, H.N.B. Garhwal University, Srinagar, Garhwal, Uttarakhand, India
ankitampharm@gmail.com
06 May, 2012
21 June, 2012
17 August, 2012
http://dx.doi.org/10.13040/IJPSR.0975-8232.3(9).3237-44
01 September, 2012
Download