FORMULATION AND IN VITRO DISSOLUTION STUDIES OF SALBUTAMOLAbstract
Salbutamol is a potent anti-asthmatic agent, is a short-acting β2-adrenergic receptor agonist act. In the present study, an attempt has been made to prepare fast dissolving tablets of Salbutamol in the oral cavity with enhanced dissolution rate and to achieve better patient compliance. The tablets were prepared with four superdisintegrants e.g., Sodium starch glycolate, Cross-povidone, Cross-carmellose sodium, Pregelatinized starch by direct compression method. The pre-compression parameters of mixed blend were examined for angle of repose, bulk density, tapped density, Compressibility index and Hausner’s ratio. The tablets were evaluated for hardness, friability, weight variation, disintegration time, dissolution rate, content uniformity and drug content. It was concluded that the fast dissolving tablets with proper hardness, rapidly disintegrate with enhanced dissolution can be made using selected superdisintegrants. Among all formulations, batch D4 was considered as best since it showed enhanced dissolution, which leads to improved bioavailability, improved effectiveness and hence better patient compliance.
G. Nageswara Rao*, M. Aparna, Uzma Javeria, S. Sharath Kumar Goud, and G. Ravi
Department of Pharmaceutical Chemistry, Telangana University, Nizamabad-503 322, Andhra Pradesh, India
30 May, 2012
19 August, 2012
19 September, 2012
01 October, 2012