FORMULATION AND IN-VITRO EVALUATION OF DRY EMULSION OF MEFENAMIC ACID IN HARD VEGETARIAN CAPSULESAbstract
The dry emulsion formulation aims to improve the solubility and dissolution of mefenamic acid. Dry emulsions are attractive because they are physically and micro biologically stable formulations. They represent a potential oral drug delivery system for lipophilic and low soluble drug substances. Dry emulsions can be prepared by spray drying, lyophilisation and rotary evaporation. Dry emulsion prepared here was by lyophilisation using capryol as the lipid phase and HPMC as the carrier. Mefenamic acid is the drug of choice which belongs to non-steroidal anti-inflammatory drug category. It is used as anti-pyretic, analgesic and anti-rheumatic and is used in the treatment of mild to moderate pain, including menstrual pain. The dry emulsion is formed by freeze drying method and incorporated in HPMC (hydroxyl propyl methyl cellulose) capsules, which provides a vegetarian environment and is a good alternative to gelatin. The formed dry emulsion formulation has been evaluated for the respective parameters in comparison with the marketed variant and the results are obtained.
M. S. Reddy * and S. Tanmayee
Centre for Pharmaceutical Sciences, IST, Jawaharlal Nehru Technological University, Kukatpally, Hyderabad, Telangana, India.
06 December, 2017
29 May, 2018
08 June, 2018
01 September, 2018