FORMULATION AND IN-VITRO EVALUATION OF MUCOADHESIVE BILAYERED BUCCAL TABLETS OF ROSUVASTATIN CALCIUMAbstract
The purpose of this research work was to establish mucoadhesive buccal device of Rosuvastatin Calcium(RC) in the form of bilayered tablet. The tablets were prepared using natural gums like Xanthan gum, Tamarid gum, Gellan gum and Chitosan as bioadhesive polymers to impart mucoadhesion as well as permeation enhancement property to the formulation. Ethyl cellulose & magnesium stearate were added to act as an impermeable backing layer which gives unidirectional buccal drug delivery. Buccal devices were evaluated for different parameters such as weight uniformity, content uniformity, thickness, hardness, surface pH, swelling index, ex vivo mucoadhesive strength, ex vivo mucoadhesive time, in vitro drug release, and in vitro drug permeation. The results of study revealed that the formulation containing a combination of polymers like chitosan and natural gums shows suitatble drug permeation rate as well as mucoadhesive strength. So, it can be concluded that buccal mucoadhesive tablet is potential way of delivering Rosuvastatin in order to prevent its extensive first pass metabolism and to improve its bioavailibility.
Amish V. Panchal*, Markand Mehta, Viral H. Shah, Umesh Upadhyay
Department of Pharmaceutics, Sigma institute of Pharmacy, Baroda, Gujarat, India
20 April, 2012
09 May, 2012
27 July, 2012
01 August, 2012