FORMULATION AND OPTIMIZATION OF FAST DISSOLVING TABLETS OF OLANZAPINE USING VACUUM DRYING TECHNIQUE BY 22 FACTORIAL DESIGN
AbstractThe purpose of this research was to develop fast dissolving tablets of olanzapine and to optimize the processing variables. Tablets containing olanzapine, camphor, crosscarmellose, and directly compressible lactose were prepared by direct compression technique. The tablets were compressed and later exposed to vacuum. Sublimation of camphor from tablets resulted in superior fast dissolving tablets. The tablets were evaluated for percentage friability, wetting time, and disintegration time. In this investigation, a 22 full factorial design was used to investigate the joint influence of 2 formulation variables: amount of camphor and crosscarmellose. A checkpoint batch was also prepared to prove the validity of the evolved mathematical model. The results of multiple linear regression analysis revealed that for obtaining a rapidly disintegrating dosage form, tablets should be prepared using an optimum concentration of camphor and a higher percentage of crosscarmellose. The systematic formulation approach helped in understanding the effect of formulation processing variables
Article Information
40
1594-1599
528
1418
English
Ijpsr
Sudhakar Sekar*, V. Malarvizhi and C. Vijaya
Faculty of Pharmacy, Masterskill University College of Health Sciences, Cheras- 43200, Selangor DE, Malaysia
18 February, 2011
25 April, 2011
08 May, 2011
http://dx.doi.org/10.13040/IJPSR.0975-8232.2(6).1594-99
01 June, 2011
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