FORMULATION, CHARACTERIZATION AND ANTIBACTERIAL ACTIVITY EVALUATION OF COLLAGEN BASED SILVER NANOPARTICLEAbstract
Nanoparticles are widely used in different technological fields, one of which is medicine. Collagen is used in several types of wound dressing. A silver nanoparticle is used as an antimicrobial agent to reduce microbial infection. In this research work, we have synthesized silver nanoparticles with collagen and studied for antibacterial activity against aureus (S. aureus), Escherichia coli (E. coli), and Pseudomonas aeruginosa (P. aeruginosa). The silver content and cell line study results reveal that the formulation contains less concentration of silver (0.109 µg /ml), and it is not toxic in 3T3 cell lines. Antibacterial activity of collagen-based silver nanoparticle formulation (F7) was found to be high against S. aureus, E. coli, P. aeruginosa when compared with silver nanoparticles alone.
D. L. Aswana, R. B. Roselin and V. Sankar *
Department of Pharmaceutics, PSG College of Pharmacy, Peelamedu, Coimbatore, Tamil Nadu, India.
02 June 2019
13 October 2019
19 March 2020
01 April 2020